I ride everyday to work in the Pacific Northwest 50 milesonly issue I've had with backpacks is how bad they leak. Only thing that's worked was putting my kayaking bag as a liner in then. Ride safe if your riding in the rain watch out for diesel and oil.
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I commute to work every day as long as its not freezing or raining. 85 miles round trip.
I use a backpack for anything I need for the day. I work in a prison so have to use see through mesh backpacks. It took some trial and error to find one that didn't fall apart after 70mph lol.
I wear my gear over my uniform and just leave it in control during the day.
I usually just take a backpack when riding to work. Sometimes a tank bag depending on how much stuff I have. Have to fit it into a small locked cabinet at work so I prefer a smaller backpack because of that.